Obesity-associated variants within FTO form long-range functional connections with IRX3

Genome-wide association studies (GWAS) have reproducibly associated variants within introns of FTO with increased risk for obesity and type-2 diabetes (T2D) (1–3). While the molecular mechanisms linking these noncoding variants with obesity are not immediately obvious, subsequent studies in mice dem...

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Main Authors: Smemo, Scott, Tena, Juan J., Kim, Kyoung-Han, Gamazon, Eric R., Sakabe, Noboru J., Gómez-Marín, Carlos, Aneas, Ivy, Credidio, Flavia L., Sobreira, Débora R., Wasserman, Nora F., Lee, Ju Hee, Puviindran, Vijitha, Tam, Davis, Shen, Michael, Son, Joe Eun, Vakili, Niki Alizadeh, Sung, Hoon-Ki, Naranjo, Silvia, Acemel, Rafael D., Manzanares, Miguel, Nagy, Andras, Cox, Nancy J., Hui, Chi-Chung, Gomez-Skarmeta, Jose Luis, Nóbrega, Marcelo A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113484/
https://ncbi.nlm.nih.gov/pubmed/24646999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13138
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