Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice

BACKGROUND: Considerable clinical heterogeneity has been well documented amongst individuals with autism spectrum disorders (ASD). However, little is known about the biological mechanisms underlying phenotypic diversity. Genetic studies have established a strong causal relationship between ASD and m...

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Autors principals: Wang, Xiaoming, Xu, Qiong, Bey, Alexandra L, Lee, Yoonji, Jiang, Yong-hui
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113141/
https://ncbi.nlm.nih.gov/pubmed/25071925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2392-5-30
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