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Mast cell deficiency exacerbates inflammatory bowel symptoms in interleukin-10-deficient mice

AIM: To test the role of mast cells in gut inflammation and colitis using interleukin (IL)-10-deficient mice as an experimental model. METHODS: Mast cell-deficient (Kit(W-sh/W-sh)) mice were crossbred with IL-10-deficient mice to obtain double knockout (DKO) mice. The growth, mucosal damage and coli...

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Detalhes bibliográficos
Main Authors: Zhang, Hanying, Xue, Yansong, Wang, Hui, Huang, Yan, Du, Min, Yang, Qiyuan, Zhu, Mei-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112873/
https://ncbi.nlm.nih.gov/pubmed/25083083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v20.i27.9106
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