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Molecular Pathways: Can Activin-Like Kinase Pathway Inhibition Enhance the Limited Efficacy of VEGF Inhibitors?

The vascular endothelial growth factor (VEGF) pathway is critical for tumor angiogenesis. However, VEGF pathway inhibition has been limited by intrinsic and acquired resistance. Simultaneously targeting multiple steps involved in tumor angiogenesis is a potential means of overcoming this resistance....

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Detalhes bibliográficos
Main Authors: Bhatt, Rupal S., Atkins, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112731/
https://ncbi.nlm.nih.gov/pubmed/24714770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2788
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