Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium Leads to Localized Retinal Degeneration

PURPOSE. Oxidative stress in the RPE is widely accepted as a contributing factor to AMD. We have previously shown that ribozyme-mediated reduction in the antioxidant enzyme manganese superoxide dismutase (MnSOD) leads to some of the features of geographic atrophy in mice. To develop a mouse model in...

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Main Authors: Mao, Haoyu, Seo, Soo Jung, Biswal, Manas R., Li, Hong, Conners, Mandy, Nandyala, Arathi, Jones, Kyle, Le, Yun-Zheng, Lewin, Alfred S.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112607/
https://ncbi.nlm.nih.gov/pubmed/24985474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-14633
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