Anthrax Lethal Toxin Induces Acute Diastolic Dysfunction in Rats Through Disruption of the Phospholamban Signaling Network

BACKGROUND: Anthrax lethal toxin (LT), secreted by Bacillus anthracis, causes severe cardiac dysfunction by unknown mechanisms. LT specifically cleaves the docking domains of MAPKK (MEKs); thus, we hypothesized that LT directly impairs cardiac function through dysregulation of MAPK signaling mechani...

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Autori principali: Golden, Honey B., Watson, Linley E., Nizamutdinov, Damir, Feng, Hao, Gerilechaogetu, Fnu, Lal, Hind, Verma, Suresh K., Mukhopadhyay, Swagoto, Foster, Donald M., Dillmann, Wolfgang H., Dostal, D.E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112368/
https://ncbi.nlm.nih.gov/pubmed/23907041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2013.06.050
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