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p53 suppresses carcinoma progression by inhibiting mTOR pathway activation
Genetic alterations in human cancers and murine models indicate that Rb and p53 have critical tumor suppressive functions in retinoblastoma, a tumor of neural origin, and neuroendocrine tumors including small cell lung cancer and medullary thyroid cancer (MTC). Rb inactivation is the initiating lesi...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4112184/ https://ncbi.nlm.nih.gov/pubmed/24469052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.589 |
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