Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes

Progesterone and estrogen are important drivers of breast cancer proliferation. Herein, we probed ER-alpha and PR cross-talk in breast cancer models. Stable expression of PR-B in PR-low/ER+ MCF7 cells increased cellular sensitivity to estradiol and IGF1, as measured in growth assays performed in the...

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Main Authors: Daniel, Andrea R., Gaviglio, Angela L., Knutson, Todd P., Ostrander, Julie H., D’Assoro, Antonino B., Ravindranathan, Preethi, Peng, Yan, Raj, Ganesh V., Yee, Douglas, Lange, Carol A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112172/
https://ncbi.nlm.nih.gov/pubmed/24469035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.579
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