Spheroid culture of LuCaP 147 as an authentic preclinical model of prostate cancer subtype with SPOP mutation and hypermutator phenotype

LuCaP serially transplantable xenografts are valuable preclinical models of locally advanced or metastatic prostate cancer. For the first time, we recently succeeded in establishing and serially passaging spheroid cultures of several LuCaP xenografts. Here, we characterized in depth the molecular an...

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Hauptverfasser: Saar, Matthias, Zhao, Hongjuan, Nolley, Rosalie, Young, Sarah R., Coleman, Ilsa, Nelson, Peter S., Vessella, Robert L., Peehl, Donna M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112013/
https://ncbi.nlm.nih.gov/pubmed/24998678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.06.014
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