Impact of CYP2D6 polymorphisms on clinical efficacy & tolerability of metoprolol tartrate

Metoprolol is a selective β-1 adrenergic receptor blocker that undergoes extensive metabolism by the polymorphic enzyme, CYP2D6. Our objective was to investigate the influence of CYP2D6 polymorphisms on efficacy and tolerability of metoprolol tartrate. 281 study participants with uncomplicated hyper...

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Detalhes bibliográficos
Main Authors: Hamadeh, Issam S., Langaee, Taimour Y., Dwivedi, Ruti, Garcia, Sofia, Burkley, Ben M., Chapman, Arlene B., Gums, John G., Turner, Stephen T., Gong, Yan, Cooper-DeHoff, Rhonda M., Johnson, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111800/
https://ncbi.nlm.nih.gov/pubmed/24637943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2014.62
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