Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide

BACKGROUND: Nearly one-third of the United States adult population suffers from hypertension. Hydrochlorothiazide (HCTZ), one of the most commonly used medications to treat hypertension, has variable efficacy. The renal epithelial sodium channel (ENaC) provides a mechanism for fine-tuning sodium exc...

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Detalhes bibliográficos
Main Authors: Duarte, Julio D, Zineh, Issam, Burkley, Ben, Gong, Yan, Langaee, Taimour Y, Turner, Stephen T, Chapman, Arlene B, Boerwinkle, Eric, Gums, John G, Cooper-DeHoff, Rhonda M, Beitelshees, Amber L, Bailey, Kent R, Fillingim, Roger B, Kone, Bruce C, Johnson, Julie A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320544/
https://ncbi.nlm.nih.gov/pubmed/22440088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-56
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