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Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to coordination defects in mice

Selenocysteine Insertion Sequence (SECIS)-Binding Protein 2 (Secisbp2) binds to SECIS elements located in the 3′-untranslated region of eukaryotic selenoprotein mRNAs. It facilitates incorporation of the rare amino acid selenocysteine in response to UGA codons. Inactivation of Secisbp2 in hepatocyte...

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書誌詳細
主要な著者: Seeher, Sandra, Carlson, Bradley A., Miniard, Angela C., Wirth, Eva K., Mahdi, Yassin, Hatfield, Dolph L., Driscoll, Donna M., Schweizer, Ulrich
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111790/
https://ncbi.nlm.nih.gov/pubmed/24844465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140423
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