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A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis

The enzyme Dicer is central to the production of small silencing RNAs such as microRNAs (miRNAs) and small interfering RNAs (siRNAs). Like other insects, Drosophila melanogaster uses different Dicers to make siRNAs and miRNAs: Dicer-1 produces miRNAs from pre-miRNAs, whereas Dicer-2 generates siRNAs...

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Autors principals: Fukunaga, Ryuya, Zamore, Phillip D
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111713/
https://ncbi.nlm.nih.gov/pubmed/24787225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29066
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