Spatial–temporal FUCCI imaging of each cell in a tumor demonstrates locational dependence of cell cycle dynamics and chemoresponsiveness

The phase of the cell cycle can determine whether a cancer cell can respond to a given drug. We report here on the results of monitoring of real-time cell cycle dynamics of cancer cells throughout a live tumor intravitally using a fluorescence ubiquitination cell cycle indicator (FUCCI) before, duri...

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Bibliographic Details
Main Authors: Yano, Shuya, Zhang, Yong, Miwa, Shinji, Tome, Yasunori, Hiroshima, Yukihiko, Uehara, Fuminari, Yamamoto, Mako, Suetsugu, Atsushi, Kishimoto, Hiroyuki, Tazawa, Hiroshi, Zhao, Ming, Bouvet, Michael, Fujiwara, Toshiyoshi, Hoffman, Robert M
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111702/
https://ncbi.nlm.nih.gov/pubmed/24811200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29156
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