Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance

Glucocorticoids, such as dexamethasone, enhance protein breakdown via ubiquitin–proteasome system. However, the role of autophagy in organelle and protein turnover in the glucocorticoid-dependent atrophy program remains unknown. Here, we show that dexamethasone stimulates an early activation of auto...

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Main Authors: Troncoso, Rodrigo, Paredes, Felipe, Parra, Valentina, Gatica, Damián, Vásquez-Trincado, César, Quiroga, Clara, Bravo-Sagua, Roberto, López-Crisosto, Camila, Rodriguez, Andrea E, Oyarzún, Alejandra P, Kroemer, Guido, Lavandero, Sergio
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111682/
https://ncbi.nlm.nih.gov/pubmed/24897381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29272
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