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UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program
The removal of histone H3 lysine27 (H3K27) trimethylation mark is important for the robust induction of many cell type-specific genes during differentiation. Here we show that UTX, a H3K27 demethylase, acts as a critical switch to promote a cardiac-specific gene program. UTX-deficient ESCs failed to...
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| Main Authors: | , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2011
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4111644/ https://ncbi.nlm.nih.gov/pubmed/22192413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.11.009 |
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