Granulocyte-Colony Stimulating Factor Attenuates Oligomeric Amyloid β Neurotoxicity by Activation of Neprilysin

Soluble oligomeric amyloid β (oAβ) causes synaptic dysfunction and neuronal cell death, which are involved in the pathogenesis of Alzheimer's disease (AD). The hematopoietic growth factor granulocyte-colony stimulating factor (G-CSF) is expressed in the central nervous system (CNS) and drives n...

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Detalhes bibliográficos
Main Authors: Doi, Yukiko, Takeuchi, Hideyuki, Mizoguchi, Hiroyuki, Fukumoto, Kazuya, Horiuchi, Hiroshi, Jin, Shijie, Kawanokuchi, Jun, Parajuli, Bijay, Sonobe, Yoshifumi, Mizuno, Tetsuya, Suzumura, Akio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111597/
https://ncbi.nlm.nih.gov/pubmed/25062013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103458
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