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Homeotic function of Drosophila Bithorax-Complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the central nervous system

The Drosophila Bithorax-Complex (BX-C) Hox cluster contains a bidirectionally-transcribed miRNA locus, and a deletion mutant (∆mir) lays no eggs and is completely sterile. We show these miRNAs are expressed and active in distinct spatial registers along the anterior-posterior axis in the central ner...

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Detalhes bibliográficos
Main Authors: Garaulet, Daniel L., Castellanos, Monica, Bejarano, Fernando, Sanfilippo, Piero, Tyler, David M., Allan, Douglas W., Sánchez-Herrero, Ernesto, Lai, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111139/
https://ncbi.nlm.nih.gov/pubmed/24909902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.04.023
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