Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.
Glutathione S-transferases (EC 2.5.1.18) in mammalian cells catalyze the conjugation, and thus, the detoxication of a structurally diverse group of electrophilic environmental carcinogens and alkylating drugs, including the antineoplastic nitrogen mustards. We proposed that structural alteration of...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41111/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7667259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.18.8140 |
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