Comparable Generation of Activin-Induced Definitive Endoderm via Additive Wnt or BMP Signaling in Absence of Serum

There is considerable interest in differentiating human pluripotent stem cells (hPSCs) into definitive endoderm (DE) and pancreatic cells for in vitro disease modeling and cell replacement therapy. Numerous protocols use fetal bovine serum, which contains poorly defined factors to induce DE formatio...

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Main Authors: Teo, Adrian Kee Keong, Valdez, Ivan Achel, Dirice, Ercument, Kulkarni, Rohit N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2014
Ábhair:
Report
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110751/
https://ncbi.nlm.nih.gov/pubmed/25068117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.05.007
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