The metabolic checkpoint kinase mTOR is essential for interleukin-15 signaling during NK cell development and activation

Interleukin-15 (IL-15) controls both the homeostasis and the peripheral activation of Natural Killer (NK) cells. The molecular basis for this duality of action remains unknown. Here we report that the metabolic checkpoint kinase mTOR is activated and boosts bioenergetic metabolism upon NK cell expos...

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Autors principals: Marçais, Antoine, Cherfils-Vicini, Julien, Viant, Charlotte, Degouve, Sophie, Viel, Sébastien, Fenis, Aurore, Rabilloud, Jessica, Mayol, Katia, Tavares, Armelle, Bienvenu, Jacques, Gangloff, Yann-Gaël, Gilson, Eric, Vivier, Eric, Walzer, Thierry
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110708/
https://ncbi.nlm.nih.gov/pubmed/24973821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2936
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