The metabolic checkpoint kinase mTOR is essential for interleukin-15 signaling during NK cell development and activation

Interleukin-15 (IL-15) controls both the homeostasis and the peripheral activation of Natural Killer (NK) cells. The molecular basis for this duality of action remains unknown. Here we report that the metabolic checkpoint kinase mTOR is activated and boosts bioenergetic metabolism upon NK cell expos...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Marçais, Antoine, Cherfils-Vicini, Julien, Viant, Charlotte, Degouve, Sophie, Viel, Sébastien, Fenis, Aurore, Rabilloud, Jessica, Mayol, Katia, Tavares, Armelle, Bienvenu, Jacques, Gangloff, Yann-Gaël, Gilson, Eric, Vivier, Eric, Walzer, Thierry
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110708/
https://ncbi.nlm.nih.gov/pubmed/24973821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2936
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge