Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

BACKGROUND: The ABC transporter P-glycoprotein (P-gp) is recognized as a site for drug-drug interactions and provides a mechanistic explanation for clinically relevant pharmacokinetic interactions with digoxin. The question of whether several P-gp inhibitors may have additive effects has not yet bee...

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Bibliographic Details
Main Authors: Englund, Gunilla, Hallberg, Pär, Artursson, Per, Michaëlsson, Karl, Melhus, Håkan
Format: Artigo
Language:Inglês
Published: BioMed Central 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC411066/
https://ncbi.nlm.nih.gov/pubmed/15061868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-2-8
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