Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)

BACKGROUND: The purpose of the present study was to continue the investigation of the membrane transport mechanisms of 20-(S)-camptothecin (CPT) in order to understand the possible role of membrane transporters on its oral bioavailability and disposition. METHODS: The intestinal transport kinetics o...

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Detalhes bibliográficos
Main Authors: Lalloo, Anita K, Luo, Feng R, Guo, Ailan, Paranjpe, Pankaj V, Lee, Sung-Hack, Vyas, Viral, Rubin, Eric, Sinko, Patrick J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC411064/
https://ncbi.nlm.nih.gov/pubmed/15125776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-2-16
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