Modification of Rifamycin Polyketide Backbone Leads to Improved Drug Activity against Rifampicin-resistant Mycobacterium tuberculosis

Rifamycin B, a product of Amycolatopsis mediterranei S699, is the precursor of clinically used antibiotics that are effective against tuberculosis, leprosy, and AIDS-related mycobacterial infections. However, prolonged usage of these antibiotics has resulted in the emergence of rifamycin-resistant s...

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Main Authors: Nigam, Aeshna, Almabruk, Khaled H., Saxena, Anjali, Yang, Jongtae, Mukherjee, Udita, Kaur, Hardeep, Kohli, Puneet, Kumari, Rashmi, Singh, Priya, Zakharov, Lev N., Singh, Yogendra, Mahmud, Taifo, Lal, Rup
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110317/
https://ncbi.nlm.nih.gov/pubmed/24923585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.572636
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