Interaction between Salt-inducible Kinase 2 and Protein Phosphatase 2A Regulates the Activity of Calcium/Calmodulin-dependent Protein Kinase I and Protein Phosphatase Methylesterase-1

Salt-inducible kinase 2 (SIK2) is the only AMP-activated kinase (AMPK) family member known to interact with protein phosphatase 2 (PP2A). However, the functional aspects of this complex are largely unknown. Here we report that the SIK2·PP2A complex preserves both kinase and phosphatase activities. I...

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Detalhes bibliográficos
Main Authors: Lee, Chia-Wei, Yang, Fu-Chia, Chang, Hsin-Yun, Chou, Hanyi, Tan, Bertrand Chin-Ming, Lee, Sheng-Chung
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110314/
https://ncbi.nlm.nih.gov/pubmed/24841198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.540229
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