Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis

More effective therapies are urgently needed against hepatitis C virus (HCV), a major cause of viral hepatitis. We used in vitro protein expression and microfluidic affinity analysis to study RNA binding by the HCV transmembrane protein NS4B, which plays an essential role in HCV RNA replication. We...

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Bibliographic Details
Main Authors: Einav, Shirit, Gerber, Doron, Bryson, Paul D, Sklan, Ella H, Elazar, Menashe, Maerkl, Sebastian J, Glenn, Jeffrey S, Quake, Stephen R
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110250/
https://ncbi.nlm.nih.gov/pubmed/18758449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1490
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