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Extraction Protocol and Mass Spectrometry Method for Quantification of Doxorubicin Released Locally from Prodrugs in Tumor Tissue

The localized conversion of inactive doxorubicin prodrug chemotherapeutics to pharmacalogically active forms is difficult to quantify in mouse tumor models because it occurs only in small regions of tissue. The tumor tissue extraction protocol and LC-MS/MS analysis method described here were optimiz...

詳細記述

保存先:
書誌詳細
主要な著者: Ibsen, Stuart, Su, Yongxuan, Norton, John, Zahavy, Eran, Hayashi, Tomoko, Adams, Stephen, Wrasidlo, Wolf, Esener, Sadik
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110111/
https://ncbi.nlm.nih.gov/pubmed/23832932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jms.3221
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