Extraction Protocol and Mass Spectrometry Method for Quantification of Doxorubicin Released Locally from Prodrugs in Tumor Tissue

The localized conversion of inactive doxorubicin prodrug chemotherapeutics to pharmacalogically active forms is difficult to quantify in mouse tumor models because it occurs only in small regions of tissue. The tumor tissue extraction protocol and LC-MS/MS analysis method described here were optimiz...

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Bibliographic Details
Main Authors:	Ibsen, Stuart, Su, Yongxuan, Norton, John, Zahavy, Eran, Hayashi, Tomoko, Adams, Stephen, Wrasidlo, Wolf, Esener, Sadik
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4110111/ https://ncbi.nlm.nih.gov/pubmed/23832932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jms.3221
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Extraction Protocol and Mass Spectrometry Method for Quantification of Doxorubicin Released Locally from Prodrugs in Tumor Tissue

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