DevR (DosR) mimetic peptides impair transcriptional regulation and survival of Mycobacterium tuberculosis under hypoxia by inhibiting the autokinase activity of DevS sensor kinase

BACKGROUND: Two-component systems have emerged as compelling targets for antibacterial drug design for a number of reasons including the distinct histidine phosphorylation property of their constituent sensor kinases. The DevR-DevS/DosT two component system of Mycobacterium tuberculosis (M. tb) is e...

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Autores principales: Kaur, Kohinoor, Taneja, Neetu Kumra, Dhingra, Sakshi, Tyagi, Jaya S
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110071/
https://ncbi.nlm.nih.gov/pubmed/25048654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-14-195
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