Appropriate DevR (DosR)-Mediated Signaling Determines Transcriptional Response, Hypoxic Viability and Virulence of Mycobacterium tuberculosis

BACKGROUND: The DevR(DosR) regulon is implicated in hypoxic adaptation and virulence of Mycobacterium tuberculosis. The present study was designed to decipher the impact of perturbation in DevR-mediated signaling on these properties. METHODOLOGY/PRINCIPAL FINDINGS: M. tb complemented (Comp) strains...

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Detalhes bibliográficos
Main Authors: De Majumdar, Shyamasree, Vashist, Atul, Dhingra, Sakshi, Gupta, Rajesh, Singh, Alka, Challu, Vijay K., Ramanathan, V. D., Kumar, Prahlad, Tyagi, Jaya Sivaswami
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338549/
https://ncbi.nlm.nih.gov/pubmed/22563409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035847
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