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Reversal of RNA-dominance by displacement of protein sequestered on triplet repeat RNA
Genomic expansions of simple tandem repeats can give rise to toxic RNAs that contain expanded repeats. In myotonic dystrophy the expression of expanded CUG repeats (CUG(exp)) causes abnormal regulation of alternative splicing and neuromuscular dysfunction. Here we use a transgenic mouse model to sho...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109973/ https://ncbi.nlm.nih.gov/pubmed/19608921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1173110 |
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