Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate

Sphingosine-1-phosphate (S1P) mediates several cytoprotective functions of HDL. apoM acts as a S1P binding protein in HDL. Erythrocytes are the major source of S1P in plasma. After glomerular filtration, apoM is endocytosed in the proximal renal tubules. Human or murine HDL elicited time- and dose-d...

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Autors principals: Sutter, Iryna, Park, Rebekka, Othman, Alaa, Rohrer, Lucia, Hornemann, Thorsten, Stoffel, Markus, Devuyst, Olivier, von Eckardstein, Arnold
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109767/
https://ncbi.nlm.nih.gov/pubmed/24950692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M050021
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