Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans

While genetic determinants strongly influence HDL cholesterol (HDLc) levels, most genetic causes underlying variation in HDLc remain unknown. We aimed to identify novel rare mutations with large effects in candidate genes contributing to extreme HDLc in humans, utilizing family-based Mendelian genet...

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Bibliographic Details
Main Authors: Singaraja, Roshni R., Tietjen, Ian, Hovingh, G. Kees, Franchini, Patrick L., Radomski, Chris, Wong, Kenny, vanHeek, Margaret, Stylianou, Ioannis M., Lin, Linus, Wang, Liangsu, Mitnaul, Lyndon, Hubbard, Brian, Winther, Michael, Mattice, Maryanne, Legendre, Annick, Sherrington, Robin, Kastelein, John J., Akinsanya, Karen, Plump, Andrew, Hayden, Michael R.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2014
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109763/
https://ncbi.nlm.nih.gov/pubmed/24891332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M048710
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