The role of β-cell GLP-1 signaling in glucose regulation and response to diabetes drugs

Glucagon-like peptide-1 (GLP-1), an insulinotropic peptide released from the intestine after eating, is essential for normal glucose tolerance (GT). To determine whether this effect is mediated directly by GLP-1 receptors (GLP1R) on islet β-cells, we developed mice with β-cell specific knockdown of...

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Detalhes bibliográficos
Main Authors: Smith, Eric P., An, Zhibo, Wagner, Constance, Lewis, Alfor G., Cohen, Eric B., Li, Bailing, Mahbod, Parinaz, Sandoval, Darleen, Perez-Tilve, Diego, Tamarina, Natalia, Philipson, Louis H., Stoffers, Doris A., Seeley, Randy J., D’Alessio, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109713/
https://ncbi.nlm.nih.gov/pubmed/24836562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.04.005
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