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Neuronal GLP1R mediates liraglutide’s anorectic but not glucose-lowering effect

Glucose control and weight loss are cornerstones of type 2 diabetes treatment. Currently, only glucagon-like peptide-1 (GLP1) analogs are able to achieve both weight loss and glucose tolerance. Both glucose and body weight are regulated by the brain, which contains GLP1 receptors (GLP1R). Even thoug...

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Autors principals: Sisley, Stephanie, Gutierrez-Aguilar, Ruth, Scott, Michael, D’Alessio, David A., Sandoval, Darleen A., Seeley, Randy J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038572/
https://ncbi.nlm.nih.gov/pubmed/24762441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72434
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