Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

Interactions between the host and gut microbial community likely contribute to Crohn disease (CD) pathogenesis; however, direct evidence for these interactions at the onset of disease is lacking. Here, we characterized the global pattern of ileal gene expression and the ileal microbial community in...

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Main Authors: Haberman, Yael, Tickle, Timothy L., Dexheimer, Phillip J., Kim, Mi-Ok, Tang, Dora, Karns, Rebekah, Baldassano, Robert N., Noe, Joshua D., Rosh, Joel, Markowitz, James, Heyman, Melvin B., Griffiths, Anne M., Crandall, Wallace V., Mack, David R., Baker, Susan S., Huttenhower, Curtis, Keljo, David J., Hyams, Jeffrey S., Kugathasan, Subra, Walters, Thomas D., Aronow, Bruce, Xavier, Ramnik J., Gevers, Dirk, Denson, Lee A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109533/
https://ncbi.nlm.nih.gov/pubmed/25003194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75436
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