Age-of-Diagnosis Dependent Ileal Immune Intensification and Reduced Alpha-Defensin in Older versus Younger Pediatric Crohn Disease Patients despite Already Established Dysbiosis

Age-of-diagnosis associated variation in disease location and antimicrobial sero-reactivity has suggested fundamental differences in pediatric Crohn Disease (CD) pathogenesis. This variation may be related to pubertal peak incidence of ileal involvement and Peyer’s patches maturation, represented by...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Haberman, Yael, Schirmer, Melanie, Dexheimer, Phillip J., Karns, Rebekah, Braun, Tzipi, Kim, Mi-Ok, Walters, Thomas D., Baldassano, Robert N., Noe, Joshua D, Rosh, Joel, Markowitz, James, Crandall, Wallace V., Mack, David R., Griffiths, Anne M., Heyman, Melvin B., Baker, Susan S., Kellermayer, Richard, Moulton, Dedrick, Patel, Ashish S., Gulati, Ajay S., Steiner, Steven J, LeLeiko, Neal, Otley, Anthony, Oliva-Hemker, Maria, Ziring, David, Kirschner, Barbara S, Keljo, David J, Guthery, Stephen L., Cohen, Stanley A, Snapper, Scott, Evans, Jonathan, Dubinsky, Marla, Aronow, Bruce, Hyams, Jeffrey S., Kugathasan, Subra, Huttenhower, Curtis, Xavier, Ramnik J., Denson, Lee A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375755/
https://ncbi.nlm.nih.gov/pubmed/30542108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-018-0114-4
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