Age-of-Diagnosis Dependent Ileal Immune Intensification and Reduced Alpha-Defensin in Older versus Younger Pediatric Crohn Disease Patients despite Already Established Dysbiosis

Age-of-diagnosis associated variation in disease location and antimicrobial sero-reactivity has suggested fundamental differences in pediatric Crohn Disease (CD) pathogenesis. This variation may be related to pubertal peak incidence of ileal involvement and Peyer’s patches maturation, represented by...

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Gepubliceerd in:Mucosal Immunol
Hoofdauteurs: Haberman, Yael, Schirmer, Melanie, Dexheimer, Phillip J., Karns, Rebekah, Braun, Tzipi, Kim, Mi-Ok, Walters, Thomas D., Baldassano, Robert N., Noe, Joshua D, Rosh, Joel, Markowitz, James, Crandall, Wallace V., Mack, David R., Griffiths, Anne M., Heyman, Melvin B., Baker, Susan S., Kellermayer, Richard, Moulton, Dedrick, Patel, Ashish S., Gulati, Ajay S., Steiner, Steven J, LeLeiko, Neal, Otley, Anthony, Oliva-Hemker, Maria, Ziring, David, Kirschner, Barbara S, Keljo, David J, Guthery, Stephen L., Cohen, Stanley A, Snapper, Scott, Evans, Jonathan, Dubinsky, Marla, Aronow, Bruce, Hyams, Jeffrey S., Kugathasan, Subra, Huttenhower, Curtis, Xavier, Ramnik J., Denson, Lee A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375755/
https://ncbi.nlm.nih.gov/pubmed/30542108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-018-0114-4
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