Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients

Covalent protein modifications by electrophilic acyl glucuronide (AG) metabolites are hypothetical causes of hypersensitivity reactions associated with certain carboxylate drugs. The complex rearrangements and reactivities of drug AG have been defined in great detail, and protein adducts of carboxyl...

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Autores principales: Hammond, Thomas G., Meng, Xiaoli, Jenkins, Rosalind E., Maggs, James L., Castelazo, Anahi Santoyo, Regan, Sophie L., Bennett, Stuart N. L., Earnshaw, Caroline J., Aithal, Guruprasad P., Pande, Ira, Kenna, J. Gerry, Stachulski, Andrew V., Park, B. Kevin, Williams, Dominic P.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2014
Materias:
Toxicology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109494/
https://ncbi.nlm.nih.gov/pubmed/24902585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.215079
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