Sigma-1 Receptor Antagonism Restores Injury-Induced Decrease of Voltage-Gated Ca(2+) Current in Sensory Neurons

Sigma-1 receptor (σ1R), an endoplasmic reticulum–chaperone protein, can modulate painful response after peripheral nerve injury. We have demonstrated that voltage-gated calcium current is inhibited in axotomized sensory neurons. We examined whether σ1R contributes to the sensory dysfunction of volta...

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Bibliographic Details
Main Authors: Pan, Bin, Guo, Yuan, Kwok, Wai-Meng, Hogan, Quinn, Wu, Hsiang-en
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2014
Subjects:
Neuropharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109486/
https://ncbi.nlm.nih.gov/pubmed/24891452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.214320
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