Bone marrow endothelium-targeted therapeutics for metastatic breast cancer

Effective treatment of cancer metastasis to the bone relies on bone marrow drug accumulation. The surface proteins in the bone marrow vascular endothelium provide docking sites for targeted drug delivery. We have developed a thioaptamer that specifically binds to E-selectin that is overexpressed in...

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Autores principales: Mai, Junhua, Huang, Yi, Mu, Chaofeng, Zhang, Guodong, Xu, Rong, Guo, Xiaojing, Xia, Xiaojun, Volk, David E., Lokesh, Ganesh L., Thiviyanathan, Varatharasa, Gorenstein, David G., Liu, Xuewu, Ferrari, Mauro, Shen, Haifa
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109393/
https://ncbi.nlm.nih.gov/pubmed/24818768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.04.057
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