Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells

Down’s syndrome (DS), caused by trisomy of human chromosome 21, is the most common genetic cause of intellectual disability. Here we use induced pluripotent stem cells (iPSCs) derived from DS patients to identify a role for astrocytes in DS pathogenesis. DS astroglia exhibit higher levels of reactiv...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Chen, Chen, Jiang, Peng, Xue, Haipeng, Peterson, Suzanne E., Tran, Ha T., McCann, Anna E., Parast, Mana M., Li, Shenglan, Pleasure, David E., Laurent, Louise C., Loring, Jeanne F., Liu, Ying, Deng, Wenbin
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109022/
https://ncbi.nlm.nih.gov/pubmed/25034944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5430
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki