Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells

Down’s syndrome (DS), caused by trisomy of human chromosome 21, is the most common genetic cause of intellectual disability. Here we use induced pluripotent stem cells (iPSCs) derived from DS patients to identify a role for astrocytes in DS pathogenesis. DS astroglia exhibit higher levels of reactiv...

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書誌詳細
主要な著者: Chen, Chen, Jiang, Peng, Xue, Haipeng, Peterson, Suzanne E., Tran, Ha T., McCann, Anna E., Parast, Mana M., Li, Shenglan, Pleasure, David E., Laurent, Louise C., Loring, Jeanne F., Liu, Ying, Deng, Wenbin
フォーマット: Artigo
言語:Inglês
出版事項: Nature Pub. Group 2014
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Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109022/
https://ncbi.nlm.nih.gov/pubmed/25034944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5430
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