Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells

Down’s syndrome (DS), caused by trisomy of human chromosome 21, is the most common genetic cause of intellectual disability. Here we use induced pluripotent stem cells (iPSCs) derived from DS patients to identify a role for astrocytes in DS pathogenesis. DS astroglia exhibit higher levels of reactiv...

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Detalhes bibliográficos
Main Authors: Chen, Chen, Jiang, Peng, Xue, Haipeng, Peterson, Suzanne E., Tran, Ha T., McCann, Anna E., Parast, Mana M., Li, Shenglan, Pleasure, David E., Laurent, Louise C., Loring, Jeanne F., Liu, Ying, Deng, Wenbin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109022/
https://ncbi.nlm.nih.gov/pubmed/25034944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5430
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