Alpha blockade potentiates CPVT therapy in calsequestrin-mutant mice

BACKGROUND: Spontaneous calcium release evoking delayed after-depolarization is believed to cause CPVT, a lethal human arrhythmia provoked by exercise or emotional stress. Beta-adrenergic blockers are the drug of choice, but fail to achieve complete arrhythmia control in some patients. These individ...

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Autori principali: Kurtzwald-Josefson, Efrat, Hochhauser, Edith, Bogachenko, Katia, Harun-Khun, Shiraz, Katz, Guy, Aravot, Dan, Seidman, Jonathan G., Seidman, Christine E., MichaelEldar, Shainberg, Asher, Arad, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108570/
https://ncbi.nlm.nih.gov/pubmed/24768611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2014.04.030
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