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Targeting the IL-12/IL-23 axis: An alternative approach to removing tumor induced immune suppression
Combination immune checkpoint blockade has demonstrated significant clinical responses in cancers infiltrated by T cells. Many tumors contain high proportions of myeloid cells and these can secrete immunosuppressive cytokines like IL-23. Our data suggest the clinical potential of using anti-CD40 (pu...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4108456/ https://ncbi.nlm.nih.gov/pubmed/25083324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.28964 |
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