The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6

The physiological functions of members of the tumor-necrosis factor (TNF) receptor (TNFR)–associated factor (TRAF) family in T cell immunity are not well understood. We found that in the presence of interleukin 6 (IL-6), naive TRAF5-deficient CD4(+) T cells showed an enhanced ability to differentiat...

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Detalhes bibliográficos
Main Authors: Nagashima, Hiroyuki, Okuyama, Yuko, Asao, Atsuko, Kawabe, Takeshi, Yamaki, Satoshi, Nakano, Hiroyasu, Croft, Michael, Ishii, Naoto, So, Takanori
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108451/
https://ncbi.nlm.nih.gov/pubmed/24681564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2863
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