A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators

Botulinum neurotoxin (BoNT) is a potent and potentially lethal bacterial toxin that binds to host motor neurons, is internalized into the cell, and cleaves intracellular proteins that are essential for neurotransmitter release. BoNT is comprised of a heavy chain (HC), which mediates host cell bindin...

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Bibliographic Details
Main Authors: Caglič, Dejan, Bompiani, Kristin M., Krutein, Michelle C., Čapek, Petr, Dickerson, Tobin J.
Format: Artigo
Language:Inglês
Published: MyJove Corporation 2013
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107797/
https://ncbi.nlm.nih.gov/pubmed/24430674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/50908
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