Identification of Clinically Viable Quinolinol Inhibitors of Botulinum Neurotoxin A Light Chain

[Image: see text] Botulinum neurotoxins (BoNT) are the most potent toxins known and a significant bioterrorist threat. Few small molecule compounds have been identified that are active in cell-based or animal models, potentially due to toxin enzyme plasticity. Here we screened commercially available...

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Detalhes bibliográficos
Main Authors: Caglič, Dejan, Krutein, Michelle C., Bompiani, Kristin M., Barlow, Deborah J., Benoni, Galit, Pelletier, Jeffrey C., Reitz, Allen B., Lairson, Luke L., Houseknecht, Karen L., Smith, Garry R., Dickerson, Tobin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983388/
https://ncbi.nlm.nih.gov/pubmed/24387280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4012164
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