Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model

Fmr1 knock-out (ko) mice display key features of fragile X syndrome (FXS), including delayed dendritic spine maturation and FXS-associated behaviors, such as poor socialization, obsessive-compulsive behavior, and hyperactivity. Here we provide conclusive evidence that matrix metalloproteinase-9 (MMP...

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Auteurs principaux: Sidhu, Harpreet, Dansie, Lorraine E., Hickmott, Peter W., Ethell, Douglas W., Ethell, Iryna M.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107404/
https://ncbi.nlm.nih.gov/pubmed/25057190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1162-14.2014
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