Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in Ca(V)2.1 knockin migraine mice

Familial hemiplegic migraine type 1 (FHM1), a monogenic subtype of migraine with aura, is caused by gain-of-function mutations in Ca(V)2.1 (P/Q-type) calcium channels. In FHM1 knockin mice, excitatory neurotransmission at cortical pyramidal cell synapses is enhanced, but inhibitory neurotransmission...

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Bibliographic Details
Main Authors: Vecchia, Dania, Tottene, Angelita, van den Maagdenberg, Arn M.J.M., Pietrobon, Daniela
Format: Artigo
Language:Inglês
Published: Academic Press 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107271/
https://ncbi.nlm.nih.gov/pubmed/24907493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.05.035
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