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Identification of the Glucosyltransferase That Converts Hydroxymethyluracil to Base J in the Trypanosomatid Genome

O-linked glucosylation of thymine in DNA (base J) is an important regulatory epigenetic mark in trypanosomatids. β-d-glucopyranosyloxymethyluracil (base J) synthesis is initiated by the JBP1/2 enzymes that hydroxylate thymine, forming 5-hydroxymethyluracil (hmU). hmU is then glucosylated by a previo...

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Detalhes bibliográficos
Main Authors: Bullard, Whitney, Lopes da Rosa-Spiegler, Jessica, Liu, Shuo, Wang, Yinsheng, Sabatini, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106341/
https://ncbi.nlm.nih.gov/pubmed/24891501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.579821
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