Senescent cells harbour features of the cancer epigenome

Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes a limit on the proliferative potential of normal cells that all cancer cells must bypass. Here we show by whole-genome s...

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Detalhes bibliográficos
Main Authors: Cruickshanks, Hazel A., McBryan, Tony, Nelson, David M., VanderKraats, Nathan D., Shah, Parisha P., van Tuyn, John, Rai, Taranjit Singh, Brock, Claire, Donahue, Greg, Dunican, Donncha S., Drotar, Mark E., Meehan, Richard R., Edwards, John R., Berger, Shelley L., Adams, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106249/
https://ncbi.nlm.nih.gov/pubmed/24270890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2879
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