Surfactant protein C peptides with salt-bridges (“ion-locks”) promote high surfactant activities by mimicking the α-helix and membrane topography of the native protein

Background. Surfactant protein C (SP-C; 35 residues) in lungs has a cationic N-terminal domain with two cysteines covalently linked to palmitoyls and a C-terminal region enriched in Val, Leu and Ile. Native SP-C shows high surface activity, due to SP-C inserting in the bilayer with its cationic N-te...

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Detalhes bibliográficos
Main Authors: Walther, Frans J., Waring, Alan J., Hernández-Juviel, José M., Ruchala, Piotr, Wang, Zhengdong, Notter, Robert H., Gordon, Larry M.
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2014
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106191/
https://ncbi.nlm.nih.gov/pubmed/25083348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.485
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